Characterization of Plasmids that Confer Inducible Resistance to 14-Membered Macrolides and Streptogramin Type B Antibiotics inStaphylococcus aureus
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منابع مشابه
Inducible macrolides-lincosamides-streptogramin B resistance in Bacteroides species.
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Streptogramin antibiotics are comprised of two distinct chemical components: the type A polyketides and the type B cyclic depsipeptides. Clinical resistance to the type B streptogramins can occur via enzymatic degradation catalyzed by the lyase Vgb or by target modification through the action of Erm ribosomal RNA methyltransferases. We have prepared through chemical and chemo-enzymatic approach...
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A gene which mediates inducible resistance to macrolides, lincosamides, and streptogramin B antibiotics, designated erm(33), was detected on the Staphylococcus sciuri plasmid pSCFS1. Analysis of the erm(33) reading frame suggested that this gene was the product of a recombination between an erm(C) gene and an erm(A) gene. Such a recombination event is a novel observation for erm genes.
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A set of plasmids conferring resistance to several antibiotics, including the combination of trimethoprim and sulfamethoxazole, has been isolated from Escherichia coli following conjugative cotransfer from a clinical isolate of Shigella flexneri 2a. One of the plasmids, pCN1, was shown by subcloning and DNA sequencing to carry a gene encoding a trimethoprim-insensitive dihydrofolate reductase i...
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ژورنال
عنوان ژورنال: Microbiology and Immunology
سال: 1990
ISSN: 0385-5600
DOI: 10.1111/j.1348-0421.1990.tb01050.x